Even though it might seem inuitive to start by choosing the largest/heaviest part of your rig first, I'd say you need to consider stuff like logistics, run-time, possible weather-proofing etc.
Power is at the heart of the matter with these kind of rigs - major implications for the weight (and cost) of it all. I'd say (and I think you'll find a general concensus in here on it) there are 2 approaches to power ....
1) Use 12V lead-acid batteries and (the right type of) car amplifiers. This the simplest way - there'll be a bif DIY to achieve the right wiring etc. - but nothing too tricky. Car amplifiers are usually bridgeable i.e. 2 channels can bridge to 1 or 4 channels can be bridged to 2 ... this also helps to achieve a sensible impedance match to PA-type drivers which are nearly always 8 ohms. Also, car amps usually have built-in filters to use as basic crossover.
Disadvantage is the weight - especially if you need long run-times.
2) Use chip-amp modules and (possibly) lithium batteries. The latter could be (for instance) an e-bike battery at nominal voltages of 24, 36, or 48. Advantages are power-efficiency and weight. But you'll need to DIY up some kind of casing for the modules and probably some kind of crossover (could be analogue or some kind of DSP). You might very well need some signal gain to run the chip-amp modules from usual sources like laptops, phones/ipads etc. .... so your amplifier enclosure may need to supply 2 or more voltages to various things ... more complications. Chip-amp modules are nearly always rated into 4 ohm loads (or lower) - which is fine when you using multiple drivers - not so much if you run a single driver per amp channel.
This approach can ge quite costly - when it comes to chunky lithium batteries. Also - if you go with this approach, get some help with it unless you're fairly savvy with electronics, wiring, and have access to a decent workshop/tools etc.
Now you mention the Cubo 15 for bass ... I'd say that could very well be a good choice (but not the only show in town). There's a pair of FBT Maxx2 on ebay right now for £150 .... thats a 2-way 10" box in a quality plastic enclosure and (and I think) neo drivers - one of those would do a lovely job as mid-top above a cubo 15 (crossing somewhere around 100Hz).
If you want to give us some details like what kind of trolley you want to use, how it gets moved around, how long you need to play for, what kind of crowd you expect, what kind of budget you have ... we can probably give you useful pointers.
------------- REMEMBER....POLITICIANS AND DIAPERS SHOULD BE CHANGED OFTEN AND FOR THE SAME REASON
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